EFFECT OF ELECTROMAGNETIC FIELD WITH FREQUENCY 8 AND 50 Hz ON THE CONTRACTION OF SMOOTH MUSCLE STRIPS OF THE STOMACH OF RATS
DOI:
https://doi.org/10.17721/3041-1491/2024.11-24Keywords:
smooth muscles, isometric contraction, influence of ultra-low frequency electromagnetic fieldsAbstract
Introduction. The possibility of the influence of weak electromagnetic fields of ultra-low frequencies (EMFs of ultra-low frequencies) on living objects has long caused doubts and disputes among researchers. However, today the biological effects of electromagnetic fields have been experimentally proven at different levels of organization: at the molecular, cellular, organ and systemic levels.
Methods. Our studies used a model of evoked smooth muscle contractions by activating calcium channels in the smooth muscle cell membrane by adding hyperpotassium solution (KCl at a final concentration of 80 mM) to Krebs solution. Statistical processing of the results was carried out using generally accepted methods of variational statistics.
Results. The effect of low-frequency EMF with a frequency of 8 and 50 Hz induced by 25 μT on the contraction of the smooth muscles of the stomach of rats was investigated. It has been shown that EMFs of NLFs change the strength and nature of K+-depolarization-induced contraction of gastric smooth muscles of rats in a frequency-dependent and time-dependent manner.
Conclusions. Importantly, after cessation of exposure to LNF EMF, the force and nature of contraction return to their original values. This indicates that the effects of LNF EMF on smooth muscle contraction are reversible and do not cause prolonged relaxation processes or irreversible damage.
References
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Pophof, B., Henschenmacher, B., Kattnig, D.R., Kuhne, J., Vian, A., & Ziegelberger, G. (2023). Biological Effects of Electric, Magnetic, and Electromagnetic Fields from 0 to 100 MHz on Fauna and Flora: Workshop Report. Health Physics, 124(1), 39–52. https://doi.org/10.1097/HP.0000000000001624
Ratz, P.H., Berg, K.M., Urban, N.H., & Miner, A.S. (2005). Regulation of smooth muscle calcium sensitivity: KCl as a calcium-sensitizingstimulus. Am. J. Physiol. Cell. Physiol., 288, C769–C783. https://doi.org/10.1152/ajpcell.00529.2004
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