MULTICOMPONENT NANOSYSTEM FOR PHOTODYNAMIC ANTI-TUMOR THERAPY

Abstract

Introduction. Photodynamic therapy is a minimally invasive method of treating tumors based on photosensitizing molecules (PS) that generate reactive oxygen species (ROS) in tissue under the influence of red or infrared light excitation.

Methods. The optimum concentrations of components that can enhance the formation of (ROS) were determined by absorption and photoluminescence spectroscopy.

Results. In this work a third-generation FS with improved photosensitizing properties was prepared and stupid. This FS is a multicomponent nanosystem polymer-gold nanoparticles-temoporfin. Dynamic light scattering confirm the leveling of aggregation processes in comparison with individual temoporfin.

Conclusions. It has been proven that the combination of temporphine with gold nanoparticles incorporated into a polymer matrix can significantly enhance the effect of ROS generation due to the surface plasmon resonance of gold nanoparticles. The ternary nanosystem can be recommended for in vitro testing on cancer cells under low-power LED lamp irradiation (λ = 660 nm) for further use in photodynamic therapy. 

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