EXAMINATION OF THE EFFECT OF INDUCTIVE MODERATE HYPERTHERMIA ON SARCOMA-45 HETEROGENEITY USING MAGNETIC RESONANCE IMAGING

Abstract

Introduction. Induced moderate hyperthermia (IMH) of malignant tumors involves the use of radio frequencies for selective local action of thermal and non-thermal effects in the tumor area. The current work aims to evaluate the effect of local inductive moderate hyperthermia (IMH) on the heterogeneity of different regions of interest (ROIs) delineated on MRI scans of sarcoma-45 bearing animals using texture analysis.

Methods. The study of the experimental tumor process was conducted on non-inbred female rats (DNP “NIR”, Kyiv) with sarcoma-45. Computer planning of IMH parameters for different tumor ROIs based on Comsol Multiphysics v. 5.6. (COMSOL AB, Stockholm) software revealed that the average value of the specific absorption rate was higher in the tumor core (3.6 W/kg) than in the periphery (3.3 W/kg) or capsule (2.3 W/kg).

Results. A significant tumor volume reduction was observed on day 24 following implantation in response to IMH delivered by a MagTherm (Radmir, Ukraine) apparatus.

Conclusions. Comparative analysis of ROI heterogeneity, determined by the Moran's autocorrelation index of T1-weighted MRI scans, showed that IMH led to a 21 % decrease in the value of this texture parameter across all tumor ROIs, on average, as compared with the control group which received no treatment. The reported increase in heterogeneity of sarcoma-45 was most likely associated with a more pronounced formation of the fibrous capsule and tumor destruction in the core and periphery ROIs in response to IMH.

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